(4.8) ★★★★★ 

Getting headaches every week?

Put down the pain killers. Meet the world's most comprehensive supplement for headache relief and prevention, in a single, yummy daily serving.
  • Less frequent headaches

  • Gain lasting energy

  • Kiss brain fog goodbye

Free shipping • 30-day risk-free guarantee

You've been lied to: getting constant headaches isn't normal. 

Popping pain killers every day isn't as safe as you think it is. Frequent use of over-the-counter pain killers can lead to:
  • Liver toxicity

    Common over-the-counter pain relievers like ibuprofen and acetaminophen can damage the liver. This liver damage can range from mild enzyme elevation to severe, irreversible liver failure necessitating transplant.
  • Stomach bleeding and ulcers

    Frequent use of OTC pain killers like ibuprofen can irritate the digestive tract lining. This can cause painful ulcers in the stomach or upper intestines and may cause internal bleeding.
  • Rebound headaches

    Popping pills too often for headaches backfires badly, wiring your brain for more pain instead of less. Take this route and soon your whole life will pound along to a wicked rebound headache beat.

Choose natural relief. 
Be headache-free for good.

  • Headache-free days without ruining your liver

    Made with science's best ingredients to give you fewer headaches.
  • Long lasting energy

    Vitamins and minerals to power you through your day and never miss a beat.
  • Fight brain fog & jitters

    Real mango plus nature-derived sweeteners make for a delicious taste you'll love making a habit.
(4.8) ★★★★★
The Brain Superblend
One scoop a day keeps headaches away
Meet the world’s most comprehensive headache support formula: combining proven, science-backed ingredients in a delicious 1x/day serving.
  • Fights headaches naturally

  • Combats brain fog & low energy

  • Tasty, mango flavor 1 serving/day

Purchase options



Exceptional impact. 
Unbeatable value.

Prevents headaches
All-natural, no side effects
Doesn't damage your liver
Brain health benefits
Money-back guarantee
Created by experts for headaches
Pill after pill, day after day
Delicious. Natural. Mango.
We got tired of taking handfuls of pills every day. We worked with tastemasters over months of R&D to make The Brain Superblend yummy, delightful, and simple:
  • Stir 1 scoop into 12 ounces of water.

  • Enjoy daily. Works in yogurt & smoothies!

Perfect for anyone with a brain.

Take one scoop of The Brain Superblend daily, or when needed, if you struggle with:
  • Frequent headaches or migraine

    Struggling with hormonal, tension or stress-induced headaches? This will help.
  • Constant brain fog

    Feeling sluggish doesn't have to be your reality.
  • Lack of focus & jitterness

    Our superblend helps you feel clearer and calmer.

Hundreds of happy brains (and counting).







"Been taking this for 2 weeks, and no headaches, even during my period. Hope it continues"

Rachel T.

Taking for: hormonal headaches

"I’ve been taking it for a week and feel better than I have in years. Feeling more focused and more functional at work"

Stacy H.

Taking for: Brain Fog

"the taste is amazing and really does make it easy to make a part of my routine. I think the only thing I would note is that it did settle a bit in the glass of water after a while, but that happens with pretty much any powder supplement. I’m going to try it in yogurt which I’m excited about!"

Elizabeth B.

Taking for: stress & tension headaches

"I was skeptical but after a couple of tries, the taste really grew on me"

Steve R.

Taking for: Fatigue & Brain Fog

"I wake up, mix one scoop and chug it – great start to the day knowing I’m nourishing my brain with so much good stuff"

Sarrah B.

Taking for: stress & tension headaches

"I never keep up with my supplements b/c i hate swalloing lots of pills. the brain superblend makes it super easy"

Matt G.

Taking for: Migraine Headaches

"A little expensive but feeling the effect, and taking care of my brain is worth it"

Tyler A.

Taking for: General Brain Health

"I saved $$$ by ditching every other supplement I had"

Camron V.

Taking for: Tension Headaches

"Customer service has been impeccable. They always reply within minutes, not sure how they do it but 5 stars"

Katie H.

Taking for: stress & tension headaches

"The founders respond to every of my email. They’re clearly passionate about helping me feel better, which I love"

Marcy L.

Taking for: Migraine Headaches

"Been dealing with migraine & cluster headaches for years and I’m super impressed with the blend – it has the most bioavailable forms of every ingredient, at researched doses, which is unique to see in a supplement"

Meagan T.

Taking for: Migraine & cluster headaches

Powerful ingredients. Renewed brain power.
We put every single ingredient recommended by the American Headache Society in one scoop.
30-Day Risk-Free Promise

Supports Brain Health*

Relaxes blood vessels and supports healthy cognition.*
Helps with production of energy and protects brain cells.*
Crucial to cellular energy and mitochondrial activity.*

Protects Cellular Function*

Protects cells from damage and improves mitochondrial function, which may lessen headache occurence.*
400mcg DFE
Plays an integral role in producing neurotransmitters that regulate mood and perception of pain.*
Protects the brain against damage from oxidative stress that contributes to headaches.*
2500 IU
Enhances nerve cell function, reduces inflammation in the brain, and regulates key hormones associated with headaches.*

Enhances Mood & Focus*

Helps in the production of neurotransmitters that regulate pain perception.*
Essential for energy production in the brain which can stabilize cellular function.*
Boosts mood-regulating neurotransmitters and reduces nerve inflammation.*
Reduces inflammation*
Inhibits the release of inflammatory substances that provoke headaches and constrict blood vessels.*
Helps regulate magnesium and vitamin D, both crucial for headache management.*
This highly absorbable form of zinc regulates glutamate, a neurotransmitter linked to headaches.*
30-Day Risk-Free Promise
We’ve dealt with cluster headaches for over 20 years and know what it’s like to feel held back by endless headaches and brain fog. 
We’ve also wasted time and money on treatments that didn’t work, so our 30-Day Protection Promise refunds you if you’re not satisfied. We won't let you down.
Creating The Brain Superblend with doctors and nutritionists, we’re out to provide a comprehensive tool to help you regain control on your terms. We can't wait to see what you’ll accomplish with more headache-free days.
Jeremy & Laïla, Co-Founders

Frequently asked questions

How does it work?

The Brain Superblend is designed to be your daily ritual to help you manage headaches and migraine better. One scoop a day in 12-16 oz is all you need, preferably in the morning.

The ingredients in The Brain Superblend have all been shown in clinical trials and studies to reduce headaches, reduce pain, as well as lessen other symptoms like brain fog and anxiety.

Everyone is different, but we've leaned on the science as much as we could to create something that'll likely help improve your quality of life!

What's your money-back guarantee?

We've wasted plenty of hard-earned money on treatments that worked for others, but not us. If this happens to you, we won't leave you hanging.

Studies have shown that the ingredients take around 3 months to reach maximum benefits - but if you don't experience any benefits in your first month and aren't 100% satisfied, contact us within 30 days of your first order to initiate the process of receiving a refund for your original order.

What's special about The Brain Superblend?

With 13 active researched-backed ingredients, the Brain Superblend is the most comprehensive headache supplement available in a single serving.

We also got really tired of pills, so we made it a delicious powder instead.
How did you create the formula?
Our co-founder, Jeremy, has long struggled with his own neurological challenges in the form of cluster headache. Over the course of his medical history, he's experimented and familiarized himself with just about every potentially beneficial supplement out there to create his own support superblend.

After meeting dozens of others who expressed interest in the superblend as well, we refined the formula by partnering with nutritionists, doctors, and neurologists to ensure our blend was as effective - and safe - as possible.

We weren't done, of course; we then worked with a leading US-based R&D lab to further refine the formula, make it taste great, and source quality ingredients. The process took over a year, but we think it was worth it - and hope you agree.
Do you offer free samples?
We wish we could. The main reason we don't: it takes time to see benefits. Many see differences in a month, but studies have shown it taking up to 3 months for some that all depends on their individual needs. A short sample wouldn't tell you much about whether or not we can help.

Instead, we offer a money-back guarantee: if you don't see any benefits within your first month, we'd be happy to refund you.

Is it safe?

Safety is our top priority. The FDA has guidelines on how to manufacture supplements, called Current Good Manufacturing Processes, or cGMP. Melina blends in the United States, in facilities that follow cGMP regulations and are regularly inspected by the FDA. We only use ingredients that are classified by the FDA as Generally Recognized As Safe (GRAS) in doses that are highly effective, but well under studied upper tolerable limits.

We're also deadly serious about testing: we test 3 times for heavy metals (at higher California Prop 65 standards) and potency to ensure you're receiving something safe and at the advertised potency.

How long does it take to see results?

When taken daily, it's likely you'll see results within your first weeks. This is based on supporting published ingredient studies, which generally run for 3-4 months. They've shown that benefits generally emerge during or after the first month. Everyone's different, so results may come sooner (or later). Keep at it.

Can I take it on an empty stomach?

Sure thing! You can take our superblend on an empty stomach, and many find this works best for them to maximize absorption of the nutrients. However, everyone's body is unique, so if you find that it doesn't sit well on an empty stomach, feel free to take it with a meal or split the dose into a half dose, twice daily. 

Who is this product not for?

First, make sure you talk to your doctor about this superblend, especially if you’re taking prescription medication! All our ingredients are drug-free, but vitamins, minerals and herbs can still interact with some drugs and make them less effective. Notably, folks taking blood thinning medication should check with their doctors before taking CoQ-10 and Feverfew, both present in our formula. This list is not complete. 

Our formula was not designed for children. Pregnant and nursing people should also consult with their doctors, as the effects of our ingredients has not been studied on these folks.

The natural, holistic approach to getting rid of headaches.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or cure any disease. The information on this site is for educational purposes only and is not medical advice. Please refer to our Terms and Conditions and speak with a healthcare professional to ensure Melina is for you. Melina is for adults 18 and over.