(4.8) ★★★★★ 

Finally: all-in-one, natural migraine support.

The world's most comprehensive supplement for nutritional migraine support, in a yummy daily serving.
  • Less frequent headaches

  • Gain lasting energy

  • Kiss brain fog goodbye

Free shipping • 30-day risk-free guarantee

Tired of hearing "just drink water"? Us too.

Migraine is more than a headache, so we set out to create an all-in-one, nutritional support blend to help all aspects of your health. 
  • Feel better in weeks

    13 active studied ingredients means unequalled nutrition - just for people with migraine.
  • Everything you need, in 1 serving per day

    Say goodbye to swallowing capsules and wondering what magnesium to take: we've done the research for you.
  • Yummy, sugar-free mango flavor

    Real mango plus nature-derived sweeteners make for a delicious taste you'll love making a habit.

Migraine is associated with nutritional deficiencies. We fill them.

Headache-free days
Made with science's best ingredients to give you fewer  attacks.
Long lasting energy
Vitamins and minerals to power you through your day and never miss a beat.
Fighting brain fog
Created to give you a clear head and sharp thinking when you need it most.
Peaceful, better sleep
We hate worrying about nighttime attacks: you deserve a good night's rest (finally).



Servings per day
1 scoop
13 pills
Created by experts for migraine
Research-backed forms and doses
Money-back guarantee
Made in US-based, CGMP facility
Pill after pill, day after day
Delicious. Natural. Mango.
We got tired of taking handfuls of pills every day. We worked with tastemasters over months of R&D to make The Brain Superblend yummy, delightful, and simple:
  • Stir 1 scoop into 12 ounces of water.

  • Enjoy daily. Works in yogurt & smoothies!

(4.8) ★★★★★
The Brain Superblend
Feel better in 1-12 weeks
Meet the world’s most comprehensive migraine support formula: combining proven, science-backed ingredients in a delicious 1x/day serving.

  • Reduces headache frequency

  • Combats brain fog & low energy

  • Tasty, mango flavor 1 serving/day

Purchase options



Proof is in the sip.
Based on 36 reviews
The Brain Superblend
Jennifer (Cary, US)
A new beginning!

I have had chronic migraines for 40 years, and my preventative prescription regimen leaves me with constant brain fog - word loss. After researching how to add the best supplements to my regimen so I can reduce that medication, hopefully, I found Melina. Everything I knew I needed to order separately was in ONE product, and it was also in the proper proportions. I am in month 3 of Melina and have been successfully tapering. Jeremy and Laila treat customers as real people - with understanding and value.❤️

Melina Brain Superblend
Amanda B. (Queens, US)
No more choking down tons of pills

I love being able to take 1 drink and get all my migraine supplements as taking lots of pills was becoming cumbersome. The flavor is enjoyable. The only thing I dislike is the packaging. It's impossible to not get powder on your hands and because of the B vitamin it's a strong orange so you have to be careful to not get it on anything. A canister would be great.

Melina Brain Superblend
Kelsey B. (Arlington, US)
I feel human again

I have chronic headaches to the degree that I had a constant, migraine-level headache for more than a year that made it painful to move, and am finally finding things that are helping me feel like a human and your blend is one of them. I feel noticeably better, with more energy, on the days I drink it.

Melina Brain Superblend
Sarah M. (Nebraska City, US)
I was skeptical

I have tried so many things for my migraines, so I don’t get my hopes up, but my migraines have been reduced to one or two a month, and those are manageable with otc medications and are very short in duration! Thank you for this product!

Melina Brain Superblend
Donna W. (Philadelphia, US)
Brain superblend is easy

I like how easy it is to get all the supplements in one powder. The taste is too sweet for me. I have to pot it in my protein smoothie and add other things to lessen the sweet taste but I’m still not crazy about the taste. Maybe you can try other flavors like pineapple or chocolate.

The Brain Superblend
Claudia (Lisbon, PT)
World Class Developers and Researchers!

Jeremy and Laila are one of a kind! They have struggled so much to provide us this blend which is SO beneficial and science backed. Can't wait for worldwide shipping!!

The Brain Superblend
Amy S. (Takoma Park, US)
Unbelievably helpful!!

I've suffered from chronic migraines for years. Getting 10-15 migraines a month -- which was the pits. I just started my second bag of Melina and have to say that the improvement has been miraculous. I haven't had a migraine for almost a month. This is the longest that I've gone without a headache for ages! I was hoping that it would help, but didn't dream it could do so much! Clearly I was needing those vitamins. I don't love the stevia taste but it is a very small price to pay for migraine relief. I add lots of ice, lemon/lime juice and bubbly water to help with the taste. Highly, highly recommend!

The Brain Superblend
Debbie C. (South Hill, US)
It’s Helping!

I have seen decrease in my migraines, both in frequency and intensity. And it is so much easier to get all my supplements in one drink instead of buying, sorting and swallowing a big handful of pills. Also customer service is great!!

Melina Brain Superblend
Laura (Piscataway, US)
Amazing powder makes migraine life tolerable

I'm on my 43rd day of taking Melina every morning as the first thing I eat/drink after waking up. I'm on my 2nd bag and I love this stuff. I've tried migraine prevention supplements with similar ingredients in the past but I decided to try Melina because it had *more* of everything. Higher doses and more ingredients. I tried to tell myself "nah, you've tried stuff like this before.. don't bother" but I kept thinking "what if I just need MORE and this could work?...". I'm so glad I'm so susceptible to advertising because apparently I did need more ingredients and a higher dose because Melina WORKS.

I'm a scientist and pretty skeptical of supplements. Melina contains a whole bunch of the ingredients that have been clinically proven to help with migraines. It's different from other similar supplements in that it contains everything at a high enough dose to be effective. And in my personal experience, it is extremely effective!

I track my migraines in an app.
During the 43-day period before starting Melina, I had 8 "red" migraine days. A "red" migraine day means intense pain in my head and spreading through my neck and shoulders, and severe nausea that makes me unable to do anything. Usually my rescue med (imitrex) substantially reduces the pain on a "red" day, but I still feel weird/bad all day and sometimes need a 2nd dose of rescue med if the pain returns. A "red" migraine day is a bad day. I'm not getting much done. I'm not enjoying that day. Even if the medicine works, I'm just dragging myself through the rest of the day feeling weird, scared, and bad.

During the 43 days that I've been taking Melina, I've only had 6 days of "green" migraine. No "red" migraine days at all. On a "green" migraine? I feel a twinge of that familiar migraine pain. That pain keeps pulsing, but I can still do anything that I want to do. I just have a bit of head pain. If I try to ignore it for too long, I start to feel a little nausea. If I take my rescue med, it works and goes away entirely. No lingering migrainey feeling or weakness. My rescue med makes me feel like I never had a migraine at all. A "green" migraine day is probably similar to what a non-migraine-sufferer feels when they get a headache. I still need my imitrex to banish it, but if I don't take it... I'm not curled up in the fetal position with pain shooting through my whole body.
A "green" migraine day is still a good day. I can finish my work, I can help my kids with their homework, I can have conversations, walk the dog, enjoy food, etc.

I'm getting a little emotional typing this review. I never want to experience a "red" migraine day again and I haven't had one since starting Melina. Losing full days to do random mystery pain is horrible and if those days can be behind me, I'll take Melina forever.

The Brain Superblend
Jason M. (Wilmington, US)
Life Changing!

I’ve had chronic headaches and migraines for 24 years and this is the first time I’ve felt relief in years! After finally going off my preventative medication to try and find natural relief, I was struggling with 20+ headache or migraine days a month until I found Melina. I have been taking it for 3 weeks now and haven’t had a single headache or migraine! I cannot recommend this enough, I finally have my life back.

Melina Brain Superblend
Autumn M. (Tamworth, US)
Definitely helping

I don’t think I can go back to taking vitamins and supplements in pill form. Drinking The Brain Superblend with a big glass of water every day sets me up to feel good the whole day. I have migraine 6-10x/month for 20 years, so I use the supplement in combination with some other therapies, but Superblend is the most pleasant of them all and will be easy to maintain in my regiment. It stirs up well, has a nice taste, and no lingering aftertaste or grit. The sweeteners are also not triggering for me. I was a little concerned about feverfew every day but I’ve been feeling well enough to attempt a withdrawal from a pharmaceutical prophylactic which certainly has more side effects. Wish me luck!

Melina Brain Superblend
Bonnie F. (Farmington, US)
Brain Superblend

Great product with reduction in my migraines, on my second bag.

Melina Brain Superblend
alison k. (Longmont, US)
Awesome product great company

I have been using Melina for almost two months now. It’s amazing. It has all of the supplements that you need to support migraine health. They also clearly care about delivering the best product possible. And have amazing customer service. Product can be a little foamy when mixed but that is my smallest complaint!!!

Melina Brain Superblend
Carnisha B. (Southaven, US)
I Love This Stuff!!!

This stuff is GREAT!!! I have been suffering from migraines for years. I have had spent money on doctors, prescriptions, hospital bills, and etc. I came across this back in December and after taking it for a week I noticed an immediate change. At first I was skeptical but this stuff has changed my life I wish could give them a big hug!!! Thank Y’all So Much!!!

Melina Brain Superblend
Allison S. (San Diego, US)
Has made all of the difference!

I initially wasn't sure if my lack of symptoms were because of taking Melina or starting a new prescription. Then I forgot my Melina while travelling for work for 12 days and noticed a big difference without it and again once I got home and started again! Would love a travel friendly option to purchase 😊

Melina Brain Superblend
Maura M. (Miami, US)

I have been dealing with dizziness for 4 years and thanks to the medication I got rid of it 80% of the time. But with Melina, I don't have dizzy episodes anymore. It really gives the brain what it needs to work properly.

Melina Brain Superblend
Zach R. (Yorkville, US)
Awesome Product

I have tried every medication as well as nerve blocks and botox for my migraines. In the month since starting this product I have seen a significant difference in my migraines. So haply I found this!

Melina Brain Superblend
James B. (Escondido, US)
An athlete that’s battled migraine for years!!

Just finished my first 30 days on Melina. I had two small headaches for 30 days. That is a huge upgrade. Since 16 I have battled hemiplegic migraines giving me stroke like symptoms. They completely debilitate me forcing me to stay in a dark room for two days not eating or drinking.
The doctors would prescribe medicine that didn’t work or had side effects I wasn’t going to accept. Playing college tennis was challenging because if I had a migraine I was pretty much playing half blind and only one side of my body functional. The amount of head pain and nausea was sickening. Recently I have played pro pickleball reaching top 30 in the world for the last year and in the back of my mind I was fearing the day when I had to play with a migraine.
I had my doubts using this product , I’ve done Botox, acupuncture, been vegan for 9 years, gluten free , chocolate free , caffeine free, and tried other supplements for years. To little change of the intensity of my migraine.

So from the first 30 days on Melina I had two small headaches with no aura or nausea that I was able to sleep on and operate my normal tasks on. In comparison to my real migraines where I’m blind and the headache is so bad I cannot sleep on it.

The only feedback I would say is to deliver the product a few days earlier because I have a lapse in a day or two of no product when I do the recurrring ordering. Also I’m very health conscious , natural flavoring usually isn’t very natural, so if we could get the absolute cleanest organic product it would be preferred.

Melina Brain Superblend
Christine F. (Aurora, US)
Love it! With one tiny catch…

I have suffered with migraines my whole life and constant headaches ever since having my first baby. Once I started Melina, I didn’t have a headache or migraine for two weeks! That’s a record for me. And the first headache I got was when I got sick so that doesn’t really count. The flavor is surprisingly good even though I typically don’t like mango flavor, and I’m happy it gets me to drink a big glass of water right away in the morning. The only thing is that it tends to leave a metal taste in my mouth after I drink it. This is not surprising as they packed a ton of essential vitamins in the mix. But I found that if I drink coffee or juice right afterwards, I don’t taste the aftertaste. Even mouthwash works too. So a very simple solution for something that has amazing benefits. Thank you Melina! How about a strawberry flavor next??

The Brain Superblend
Tina G. (Indianapolis, US)
Loving the Brain Superfood !!

I am so grateful that Jeremy and Laila created this amazing supplement. I have had migraines for years and they got worse with menopause. I have tried many things, and most of them do not help. I am on my second bag and I am seeing improvement. Less migraines. On top of that, taking my Brain Superblend relaxes me as well. I advise anyone who is struggling with massive headaches or migraines to give it a try. It is changing my life.

Melina Brain Superblend
Kara W. (Superior, US)
Seriously wonderful

This product made a difference almost immediately. I went from 15-20 debilitating migraine headaches a month to one in first month of taking Melina each day. I've tried everything in 20 years of being a migraine sufferer- seriously - everything and this works. It's truly a life-saver. I'm a busy mom, partner, full-time professor, social justice advocate, and all around adventurer. I'll use Melina every day. It's the best thing. Everyone should give it a try.

Melina Brain Superblend
Sarah (Cleveland, US)

Melina Brain Superblend

The Brain Superblend
HEIDI B. (Omaha, US)
Loving the mango superblend

I did get the mango super blend , I really love it alot.

Working so far

I've tried so many supplements over the years to prevent my chronic migraines. Some helped a little, but nothing lasted. After taking this consistently for a few weeks, I've noticed a huge reduction in migraine frequency and severity. I used to have 3-4 debilitating migraines a month, but so far I only had 1 mild headache! I have more energy and can function better with the family. This supplement is a total game changer for my migraine relief.


used to have migraines like 2-3 times/week. this made them rare and less intense. life changing.

Meet our powerful ingredients.
We put every single ingredient recommended by the American Headache Society in one scoop.
30-Day Risk-Free Promise

Supports Neural Health*

Relaxes blood vessels and supports healthy cognition.*
Helps with production of energy and protects brain cells.*
Crucial to cellular energy and mitochondrial activity.*

Protects Cellular Function*

Protects cells from damage and improves mitochondrial function, which may lessen migraine symptoms.*
400mcg DFE
Plays an integral role in producing neurotransmitters that regulate mood and perception of pain.*
Protects the brain against damage from oxidative stress that contributes to migraines.*
2500 IU
Enhances nerve cell function, reduces inflammation in the brain, and regulates key hormones associated with migraines.*

Enhances Mood & Focus*

Helps in the production of neurotransmitters that regulate pain perception.*
Essential for energy production in the brain which can stabilize cellular function.*
Boosts mood-regulating neurotransmitters and reduces nerve inflammation.*
Reduces inflammation*
Inhibits the release of inflammatory substances that provoke migraines and constrict blood vessels.*
Helps regulate magnesium and vitamin D, both crucial for migraine management.*
This highly absorbable form of zinc regulates glutamate, a neurotransmitter linked to migraines.*
30-Day Risk-Free Promise
We’ve dealt with cluster headaches for over 20 years and know what it’s like to feel powerless to an invisible illness. 
We’ve also wasted time and money on treatments that didn’t work, so our 30-Day Protection Promise refunds you if you’re not satisfied. We won't let you down.
Creating The Brain Superblend with doctors and nutritionists, we’re out to provide a comprehensive tool to help you regain control on your terms. We can't wait to see what you’ll accomplish with more migraine-free days.
Jeremy & Laïla, Co-Founders

Frequently asked questions

How does it work?

The Brain Superblend is designed to be your daily ritual to help you manage migraine better. One scoop a day in 12-16 oz is all you need, preferably in the morning.

The ingredients in The Brain Superblend have all been shown in clinical trials and studies to reduce migraine attacks, reduce pain, as well as lessen other symptoms like brain fog and anxiety.

Most people experienced in those trials experienced a reduction of 50% of in the number of migraine attacks they got, along with less pain and other improvements (more energy, less anxiety, to name a few). 

Everyone is different, but we've leaned on the science as much as we could to create something that'll likely help improve your quality of life!

What's your money-back guarantee?

We've wasted plenty of hard-earned money on treatments that worked for others, but not us. If this happens to you, we won't leave you hanging.

Studies have shown that the ingredients take around 3 months to reach maximum benefits - but if you don't experience any benefits in your first month and aren't 100% satisfied, contact us within 30 days of your first order to initiate the process of receiving a refund for your original order.

What's special about The Brain Superblend?

With 13 active researched-backed ingredients, the Brain Superblend is the most comprehensive migraine supplement available in a single serving.

We also got really tired of pills, so we made it a delicious powder instead.
How did you create the formula?
Our co-founder, Jeremy, has long struggled with his own neurological challenges in the form of cluster headache. Cluster headache may have "headache" in the name, but - like migraine - is so much more than "just a headache". Over the course of his medical history, he's experimented and familiarized himself with just about every potentially beneficial supplement out there to create his own support superblend.

After meeting dozens of others who expressed interest in the superblend as well, we refined the formula by partnering with nutritionists, doctors, and neurologists to ensure our blend was as effective - and safe - as possible.

We weren't done, of course; we then worked with a leading US-based R&D lab to further refine the formula, make it taste great, and source quality ingredients. The process took over a year, but we think it was worth it - and hope you agree.
Do you offer free samples?
We wish we could. The main reason we don't: it takes time to see benefits. Many see differences in a month, but studies have shown it taking up to 3 months for some that all depends on their individual needs. A short sample wouldn't tell you much about whether or not we can help.

Instead, we offer a money-back guarantee: if you don't see any benefits within your first month, we'd be happy to refund you.

Is it safe?

Safety is our top priority. The FDA has guidelines on how to manufacture supplements, called Current Good Manufacturing Processes, or cGMP. Melina blends in the United States, in facilities that follow cGMP regulations and are regularly inspected by the FDA. We only use ingredients that are classified by the FDA as Generally Recognized As Safe (GRAS) in doses that are highly effective, but well under studied upper tolerable limits.

We're also deadly serious about testing: we test 3 times for heavy metals (at higher California Prop 65 standards) and potency to ensure you're receiving something safe and at the advertised potency.

How long does it take to see results?

When taken daily, it's likely you'll see results in your first month. This is based on supporting published ingredient studies, which generally run for 3-4 months. They've shown that benefits generally emerge during or after the first month. Everyone's different, so results may come sooner (or later). Keep at it.

You may notice words like "likely" and "generally" - it'd be irresponsible to promise the moon (we've been burned before). There's a lot we don't know about migraine, so it's impossible to guarantee results for everyone. Studies have shown benefits for many, but if you're part of the minority - we've got our 30 Day Promise to get you your money back if you're not satisfied. 

Can I take it on an empty stomach?

Sure thing! You can take our superblend on an empty stomach, and many find this works best for them to maximize absorption of the nutrients. However, everyone's body is unique, so if you find that it doesn't sit well on an empty stomach, feel free to take it with a meal or split the dose into a half dose, twice daily. 

Who is this product not for?

First, make sure you talk to your doctor about this superblend, especially if you’re taking prescription medication! All our ingredients are drug-free, but vitamins, minerals and herbs can still interact with some drugs and make them less effective. Notably, folks taking blood thinning medication should check with their doctors before taking CoQ-10 and Feverfew, both present in our formula. This list is not complete. 

Our formula was not designed for children. Pregnant and nursing people should also consult with their doctors, as the effects of our ingredients has not been studied on these folks.

I usually don't like stevia, can I still enjoy The Brain Superblend?

Absolutely! We use just a dash of pure stevia extract to gently sweeten the natural flavors to turn every scoop into a delightful ritual for you. 

That means each serving contains very small amounts of stevia. We're talking less than 1% per scoop! 

So, if you're worried about the taste, we'd still encourage you to give it a try: we worked on the flavor for 10+ months to make sure it didn't have that bitter stevia aftertaste! And if you don't like it after all, you can get a refund on your first order thanks to our 30-Day Protection Promise. 

Note that if you know stevia triggers your migraine, you might want to wait until we release a stevia-free option, which we're actively working on. 

The holistic nutritional support you need to thrive.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or cure any disease. The information on this site is for educational purposes only and is not medical advice. Please refer to our Terms of Use and speak with a healthcare professional to ensure Melina is for you. Melina is for adults 18 and over.