Science-first support for everyone with migraine.

No guessing, no anecdotes - only proven science, based on rigorous studies.
People with migraine need more to thrive.
Science has been studying migraine for decades. Studies have revealed a wealth of ingredients that help close nutrient gaps unique to people with migraine - and some that help with its worst symptoms.
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We've put everything you need in a single serving.
Dozens of studies reveal powerful ingredients that serve people with migraine. We've pulled the best into The Brain Superblend.

Riboflavin

STRONG EVIDENCE
Known to play a crucial role in cellular energy production and can help provide valuable support for people with migraine.
  • Shown to reduce migraine frequency and severity

  • Essential for cellular energy production and neurological health

  • Protects brain cells from oxidative stress

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Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in 
migraine prophylaxis. A randomized controlled trial. Neurology.

Magnesium Glycinate

STRONG EVIDENCE
Known to relax blood vessels and reduce tension, which can help alleviate migraines. Additionally, it supports neurological health by regulating neurotransmitter function and reducing the risk of migraines triggered by neurological imbalances.
  • Reduces migraine frequency and severity

  • Helps relax and dilate blood vessels, reducing vasoconstriction that can trigger migraines

  • May help alleviate migraine-related pain by blocking pain-transmitting chemicals in the brain and reducing the sensitivity of pain receptors

Methylcobalamin (B12)

Critical for nerve function and the production of neurotransmitters. It can help reduce the risk of migraines related to neurological imbalances and promote overall neurological health.
  • Supports health of nerve cells and the myelin sheath that surrounds them

  • Helps regulate homocysteine levels

  • Plays a crucial role in energy metabolism

Thiamine (B1)

Essential for maintaining healthy nerve function and may reduce the risk of migraines associated with neurological dysfunction. It supports overall neurological health, potentially preventing headaches caused by deficiencies in this crucial vitamin.
  • Important for maintaining the health and function of nerve cells

  • Involved in the conversion of carbohydrates into energy

Folate (L-5-methyl-THF)

Plays a role in neurotransmitter synthesis and supports healthy brain function.
  • Important for the production and regulation of neurotransmitters in the brain, including serotonin and dopamine

  • Plays a role in converting homocysteine into methionine, a process that helps lower homocysteine levels

  • Supports DNA synthesis and cellular repair

Zinc Picolinate

Involved in numerous neurological processes and may play a role in reducing the frequency and intensity of migraines by supporting overall neurological function and health.
  • Anti-inflammatory effects that can help reduce inflammation in blood vessels

  • Essential for a well-functioning immune system

CoQ-10

STRONG EVIDENCE
A powerful antioxidant that supports mitochondrial function and energy production in cells.
  • Reduces attack frequency, headache days, and days with nausea

  • Helps protect cells, including those in the brain, from oxidative stress

  • Improves blood vessel function and promotes vasodilation

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Sándor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology.

Feverfew

STRONG EVIDENCE
Traditionally used for migraine prevention due to its potential to reduce the frequency and severity of migraine attacks, possibly by preventing blood vessel constriction and inflammation in the brain
  • Reduces attack frequency, headache days, and days with nausea

  • Helps protect cells, including those in the brain, from oxidative stress

  • Improves blood vessel function and promotes vasodilation

Acetyl-L-Carnitine

Plays a role in energy production within brain cells and can enhance cognitive function. It may be beneficial for migraine sufferers by supporting brain health and reducing the risk of migraines related to neurological imbalances or deficiencies.
  • Supports the synthesis and release of neurotransmitters, including serotonin and dopamine

  • Plays a role in mitochondrial function and energy production within brain cells

  • Antioxidant properties and may protect brain cells from oxidative stress

Vitamin D

Vitamin D level was negatively correlated with frequency of headaches. Studies have shown that people with higher blood vitamin D levels are significantly less likely to experience migraine headaches than those with deficient vitamin D levels.
  • Anti-inflammatory properties that may help reduce inflammation in blood vessels

  • Supports the proper functioning of nerve cells and neurotransmitter regulation

Pyridoxal-5-Phosphate

Involved in neurotransmitter synthesis and may help regulate brain chemicals, potentially reducing the risk of migraines related to neurotransmitter imbalances and supporting overall neurological health.
  • Helps regulate hormonal fluctuations, potentially reducing the frequency and severity of hormonal migraines

  • Potentially decreases the risk of migraines triggered by vascular inflammation

Pantothenic Acid (B5)

Essential for nerve function and the production of neurotransmitters. It may contribute to reducing the risk of migraines related to neurological imbalances and supporting overall neurological well-being.
  • Involved in the synthesis of acetylcholine, a neurotransmitter that plays a role in brain function and muscle control

  • Helps the body respond to stress by supporting the adrenal glands

Boron Glycinate

Boron has been studied for its neurological potential; we use it in small amounts to aid in magnesium absorption.
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We only use methods and ingredients of exceptional standards.
We make products we take ourselves, but also for brothers, sisters, moms, and grandparents. Safety and quality matter.

We've worked with experts at leading facilities to create rigorous quality assurance programs that put your health and safety first.
  • Triple Verified

    Once isn't enough: our products are triple tested for potency, purity, and safety.
  • Impeccable ingredients

    Once isn't enough: our products are triple tested for potency, purity, and safety.
  • Blended in US-based FDA registered facilities

    Once isn't enough: our products are triple tested for potency, purity, and safety.
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  • Triple Verified

    Once isn't enough: our products are triple tested for potency, purity, and safety.
  • Impeccable ingredients

    We source quality ingredients from around the world and check them for quality and purity.
  • CGMP & FDA registered

    Our processes are industry leading and always blended in the United States.
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Chosen with care.
We reference research, studies, and expert advice to bring you the best forms of our ingredients that we can.

We've worked with doctors and nutritionists to select top-quality ingredients with the highest bioavailability, just for migraine sufferers.
"Based on my own research, your ingredient list hits on everything I'm looking for."

- SARAH

"Super impressed with the list of ingredients you've brought together."

– CHRIS

"WOW. My neurologist recommended every single one of the ingredients on your list."

– JEN

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Party's over, migraine.
The Brain Superblend throws a science-backed uppercut straight at your migraine. Let's stack the deck in your favor with studied ingredients and clear, powerful evidence.